valasciences公司代理

发表于2024-03-09由上海金畔生物科技有限公司

valasciences公司代理

简要描述：Vala Sciences Screen-Certified (Z’> 0.5) Cell-Imaging Kits include fixative, permeabilization, and staining solutions in amounts sufficient to stain cells cultured in five 96-well dishes.

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Vala Sciences Screen-Certified （Z’> 0.5） Cell-Imaging Kits include fixative, permeabilization, and staining solutions in amounts sufficient to stain cells cultured in five 96-well dishes.

Anti-perilipin Mouse Monoclonal Antibody

4998

#4854

Given the ever increasing interest in elucidating the mechanisms that regulate lipolysis, Vala Sciences Inc is proud to introduce a new monoclonal antibody that is excellent at visualizing perilipin in immunocytofluorescence labeling applications. This new mouse monoclonal antibody recognizes perilipin whether or not lipolytic pathways have been activated in the cell. Labeling with the antibody is exceptionally specific, with virtually no background, and the labeling pattern is very tightly associated with the outer surface of the lipid droplets, as expected for perilipin. This antibody is expected to be of high interest to researchers investigating hormonal control of lipolysis.

100 ul

Anti-perilipin mouse IgG1 monoclonal
immunogen: peptide near serine 497 of human perilipin used for Ab generation but Ab not specific to S497 phosphorylation.
species recognized: human, mouse. full-length Perilipin A

Available volume discounts and contract testing services

Anti-phosphoperilipin Mouse Monoclonal Antibody （Serine 497）

6188

#4855

Given the ever increasing interest in elucidating the mechanisms that regulate lipolysis, Vala Sciences Inc is proud to introduce a new monoclonal antibody that is excellent at visualizing perilipin in immunocytofluorescence labeling applications. This monoclonal antibody selectively recognizes perilipin that has been phosphorylated on serine 497, a site of PKA-mediated phosphorylation. Thus, for the first time, a tool is available in which phosphorylated perilipin can be visualized in fixed cells via immunocytofluorescence labeling procedures and fluorescence microscopy. This antibody is expected to be of high interest to researchers investigating hormonal control of lipolysis.

100 ul

Anti-Phosphoperilipin mouse IgG1 monoclonal
immunogen: peptide near serine 497 of human perilipin
species recognized: human, mouse. full-length Perilipin A

Available volume discounts and contract testing services

Anti-phosphoperilipin Mouse Monoclonal Antibody （Serine 522）

6188
#4856

Given the ever increasing interest in elucidating the mechanisms that regulate lipolysis, Vala Sciences Inc is proud to introduce a new monoclonal antibody that is excellent at visualizing perilipin in immunocytofluorescence labeling applications. This monoclonal antibody selectively recognizes perilipin that has been phosphorylated on serine 522, a site of PKA-mediated phosphorylation. Thus, for the first time, a tool is available in which phosphorylated perilipin can be visualized in fixed cells via immunocytofluorescence labeling procedures and fluorescence microscopy. This antibody is expected to be of high interest to researchers investigating hormonal control of lipolysis.

100 ul

Anti-Phosphoperilipin mouse IgG1 monoclonal
immunogen: peptide near serine 522 of human perilipin
species recognized: human, mouse. full-length Perilipin A

Available volume discounts and contract testing services

b-catenin Screen-Certified Cell-Imaging Kit （Z’ > 0.5）

12750元
#4807

b-catenin, the mammalian homologue of Drosophila Armadillo, is a dual purpose protein of high interest to biomedical researchers concerned with tumor formation. In normal epithelial cells, b-catenin is found at the plasma membrane. b-catenin expression and localization can be quantified in cultured cells with Vala Sciences Inc.’s b-catenin kit.

E-Cadherin Screen-Certified Cell-Imaging Kit （Z’ > 0.5）

11900
#4803

E-cadherin, a cell-cell adhesion molecule, is frequently downregulated in a wide variety of tumors （breast, skin, prostate, gastric, and colon cancers）, suggesting that it is an important tumor suppressor. E-cadherin is the major binding partner for -catenin, and E-cadherin downregulation is often accompanied by beta-catenin translocation to the nucleus, and the stimulation of cell division. E-cadherin expression and localization can be quantified in cultured cells with Vala Sciences Inc’s E-cadherin kit.

Lipid Droplet Screen-Certified Cell-Imaging Kit （Z’ > 0.5）

3740元
#4805

Lipid droplets are the primary fat storage organelles of fat cells （adipocytes）. Lipid droplet size, and number are altered by anti-diabetic and anti-obesity drugs and these effects can be quantified utilizing Vala Science Inc’s Lipid Droplet Kit. The kit can also be utilized to quantify lipid droplets in murine 3T3 L1 adipocytes.

N-Cadherin Screen-Certified Cell-Imaging Kit （Z’ > 0.5）

7395

#4802

N-cadherin, a cell-cell adhesion molecule, is upregulated in many tumor types （including breast, ovarian, prostate, and skin cancers） and may be involved in metastastic potential. N-cadherin often replaces E-cadherin during tumorigenesis, a phenomenon referred to as the “cadherin switch”. N-cadherin expression and cellular localization can be quantified in cultured cells with Vala Sciences Inc’s N-cadherin kit.

Pan-Cadherin Screen-Certified Cell-Imaging Kit （Z’ > 0.5, Mouse mAb-488）

6460
#4812

Accurate quantitation of cadherin expression and localiztion as they are related to cell adhesion, tissue structure and mitotic signaling are valuable across a variety of biomedical contexts including cell differentiation, embryonology, neurobiology, vascular pharmacology, and oncology. Vala Sciences’ Pan-cadherin assay kits, used in conjunction with Vala’s CyteSeer® automated cell image analysis software, enable precise quantification of cadherin expression and localization.

Pan-Cadherin Screen-Certified Cell-Imaging Kit （Z’ > 0.5, Mouse mAb-547）

4420

#4808

Pan-Cadherin Screen-Certified Cell-Imaging Kit （Z’ > 0.5, Rabbit Poly-488）

5100
#4809

Pan-Cadherin Screen-Certified Cell-Imaging Kit （Z’ > 0.5, Rabbit Poly-547）

5100

#4810

Perilipin Screen-Certified Cell-Imaging Kit （Z’ > 0.5）

16150
#4806

Perilipin is a protein that associates with lipid droplets in mature adipocytes and is involved in lipid droplet metabolism. The association of perilipin with lipid droplets in primary human adipocytes can be quantified through use of Vala Science Inc’s Perilipin kit.

Download the product insert

pHSLserine660 （Vala#4820）

11815

#4820

The reagents and protocol in this kit will specifically visualize Hormone Sensitive Lipase （HSL）, which has been phosphorylated on serine 660 （referenced to the sequence of rat HSL）. Phosphorylation of HSL on serine 660 occurs as HSL is activated in adipocytes exposed to agents that stimulate lipolysis of triglycerides. Reagents in this kit have been validated with both human and murine adipocytes, and will visualize pHSL-serine 660 in the red fluorescence channel. Lipid droplets will also be labeled, and will be visible in the green fluorescence channel.

PKC-Alpha Screen-Certified Cell-Imaging Kit （Z’ > 0.5）

5780
#4801

Protein kinase Cα（PKCα）, a key regulatory protein in signal transduction pathways modulating cancer and inflammation, is activated via G-protein coupled receptors, tumor promoting chemicals, and other stimuli. Activation of PKCa depends upon migration of PKCa from the cytoplasm to the cell membrane. The expression and activation of this important signal transduction molecule can be quantified in cultured cells （validated for HeLa, UMR106, or IEC18 cells）, with Vala Sciences Inc’s PKCa kit.

pPerilipin-serine497 + pHSLser660 + Lipid droplets （Vala #4822）

16915

#4822

The reagents in this kit will specifically visualize triglyceride containing lipid droplets, Perilipin A （the most common form of Perilipin in adipocytes）, which has been phosphorylated on serine 497 （human sequence, equivalent to mouse serine 492, also known as PKA phosphorylation site #5）, and Hormone Sensitive Lipase （HSL）, which has been phosphorylated on serine 660 （referenced to the sequence of rat HSL）. Phosphorylation of perilipin on serine 497 and HSL on serine 660 occurs early in the activation scheme of lipolysis in adipocytes. The reagents in this kit therefore provide tools for visualizing the appearance of two key regulators of lipid droplet metabolism （pPerilipin-serine497 and pHSL-serine660）, as well as the lipid droplets, themselves. Reagents in this kit have been validated with both human and murine adipocytes.

VE-cadherin Screen-Certified Cell-Imaging Kit （Z’ > 0.5）

9350
#4804

VE-cadherin is expressed by vascular endothelial cells where it regulates cell-cell adhesion, angiogenesis, and vascular permeability. VE-cadherin is upregulated in breast cancer and may participate in tumor-associated angiogenesis. VE-cadherin expression and localization can be quantified in cultured cells with Vala Sciences Inc’s VE-cadherin kit.

Definition of Z’: For high throughput assay development and validation, a statistic has been defined （Z’） which provides a quantitative index of the relationship between the sample to sample variability and the range of the assay （Zhang et al., 1999）. Z’ = 1-3（SDmax+SDmin）/（Xmax-Xmin） where SDmax and SDmin are the standard deviations of the maximum and minimum value samples, respectively, and Xmax and Xmin are the means of the maximum and minimum, respectively.

Z’ has a theoretic range of negative infinity to 1.0 （an ideal assay in which there is no standard deviation and finite separation between means would yield Z’ = 1.0）. A positive Z’ score is much more stringent than a p < 0.05 determination from a t-test. Z’ scores > 0.5 are excellent and indicate that an there is an extremely low probability of obtaining ‘false positives’ such assays can be used, with very high confidence, to screen libraries representing hundreds of thousands of test compounds.

Zhang, J.H., Chung, T.D. & Oldenburg, K.R. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J Biomol Screen 4, 67-73 （1999）.

2019年vala sciences价格表

发表于2024-02-29由上海金畔生物科技有限公司

Vala Sciences开发和制造动态图像细胞分析仪（KIC™）和结构照明显微镜（SIM）平台，*改变生活单细胞分析领域，实现更高选择性的药物发现和更安全的药物产品。Vala的工具集使客户能够以的度来识别新的目标和候选药物，这些药物具有高的临床成功概率和低的副作用概率。

KIC 是细胞成像领域的一次飞跃，将超快速摄像技术与高通量筛选和分析相结合，可同时查看和测量剂量治疗候选药物对数百至数千个活细胞的影响，以辨别治疗或具有高灵敏度的有害影响。

SIM结合了高的分辨率和速度（而所有竞争对手都牺牲了一个） – 对于更加疾病敏感的细节 – 采用紧凑，易于使用且价格合理的工具，几乎所有科学家都渴望，现在可以负担得起。

Vala的工具为药物提供了的成功。

VALA BREAKTHROUGHS

Vala工具为学术研究人员和制药开发人员提供的预测能力和价值。

KIC超快速摄像和细胞活动的定量分析

“观察”并量化神经元放电和肌肉细胞收缩的单细胞动力学 – 细胞健康的敏感的综合指标。
实时捕获和分析10,000多个光学蜂窝数据：每天收集多达40亿个细胞健康数据点。
预测某些常见药物副作用，其准确性为FDA批准方法的445倍。
匹配复杂动物毒性模型的预测能力为成本的1％。

SIM共聚焦技术，用于快速高内涵筛选

高吞吐量替代品的一半价格。
消除脆弱的运动部件，复杂的对齐和设置。

2019年vala sciences价格表

货号	品名	规格	价格	品牌
vala-4805	Lipid Droplet Screen-Certified Kit	1Kit	4590	valasciences
vala-4854	Anti-Perilipin 1 Antibody	100μL	5950	valasciences
vala-4855	Anti-p-Perilipin 1-Serine 497 Antibody	100μL	7650	valasciences
vala-4856	Anti-p-Perilipin 1-Serine 522 Antibody	100μL	7650	valasciences
vala-4860	Control Cell Extract, 3T3L1 Adipocytes	100μg	2125	valasciences
vala-4861	Forskolin-treated Cell Extract, 3T3L1 Adipocytes	100μg	3060	valasciences

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上海金畔生物科技有限公司是实验试剂一站式采购服务商

1：强大的进口辐射能力，血清、抗体、耗材、大部分限制进口品等。

2：产品种类齐全，经营超过700多品牌，基本涵盖所有生物实验试剂耗材。

3：提供加急服务，货品一般1-2周到货。

4：富有竞争良好的信誉，大部分客户提供货到付款服务。客户包括清华、北大、交大、复旦、中山等100多所高校，ROCHE，阿斯利康、国药、fisher等知药企。

6：我们还是Santa,Advanced Biotechnologies Inc,Athens Research & Technology,bangs,BBInternational,crystalchem,valasciences,FD Neurotechnologies,Inc. FormuMax Scientific,Inc, Genebridege, Glycotope Biotechnology GmbH; iduron,Innovative Research of America, Ludger, neuroprobe,omicronbio, Polysciences,prospecbi, valasciences,valasciences,RESEARCH DIETS,INC,sterlitech；sysy,TriLink BioTechnologies,Inc；valasciences-biochem,zyagen等几十家国外公司代理。

7：我们还是invitrogen,qiagen,MiraiBioam,sigma;neb,roche,merck, rnd,BD, GE,pierce,BioLegend等知*批发，欢迎合作。

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valasciences公司代理

valasciences公司代理

2019年vala sciences价格表

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