Isca Biochemicals由多肽科学家在英国埃克塞特成立，他们拥有先进的多肽合成设备，并拥有向生命科学界提供高质量定制和目录产品的长期经验。我们的主要业务是定制肽合成，我们还拥有一系列用于生物研究的生化标准和新型研究肽，这是由不断从文献中引入创新产品推动的，其中许多是Isca有的。我们目前提供用于信号转导、疼痛研究、食欲调节、FRET底物、免疫学研究、抗病毒肽、神经肽、蛋白酶试剂、抗菌肽和激酶试剂的研究肽，并且我们的范围不断扩大，我们的产品被各地的研究人员引用，并定期出现在高影响力期刊上。
iscabiochemicals KS-220
Tat braftide
编号KS-220
结构：
H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Aarg-Pro-Gln-PEG-Thr-Arg-His-Val-Asn-Ile-Leu-Phe-Met-OH
其他名称：
GRKKRRQRPQ-PEG-TRHVNILLFM公司
活动：
变构BRAF抑制剂
Tat-braftide是一种BRAF激酶抑制剂，由10肽抑制剂braftide-TRHVNILLFM组成，由PEG连接到细胞穿透序列Tat。Tat-braftide被设计成与BRAF激酶结构域的二聚体界面结合，因此它通过破坏BRAF二聚体来抑制BRAF蛋白激酶活性，在激酶分析中IC50为43 nM。此外，以BRAF激酶的二聚体界面为靶点导致RAF和MEK的蛋白质降解，揭示了RAF在保护大型MAPK复合物免受蛋白质降解方面的新型支架功能。Tat-braftide在多种显示RAS依赖性或独立性的细胞中显示出对WT-BRAF和BRAFG469A的有效抑制和降解。Tat公司−braftide治疗导致HCT116和HCT-15细胞的生长受到剂量依赖性抑制，EC50值分别为7.1和6.6μM，表明KRAS突变的结肠癌细胞的细胞活力受到了有效抑制。
技术数据
结构H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Aarg-Pro-Gln-PEG-Thr-Arg-His-Val-Asn-Ile-Leu-Phe-Met-OH
分子量2990.47
公式C128H227N51O30S
序列GRKKRRQRRRPQXTRHVNILLFM
修改X=PEG=-NH-CH2-CH2-O-CH2-CH2-O-CH2-CH-C=O-
溶解性和储存
溶解性可溶于水
外观冻干固体
储存干燥、冷冻、避光保存
批次特定数据
hplc测定纯度>95%
iscabiochemicals新增产品列表
2022
October
KS-220 Tat-braftide Allosteric BRAF inhibitor
September
PP-360 SMRwt Disrupts the Nef-mortalin interaction, anti-metastatic
AM-350 Urumin Antiviral host defense peptide
CY-040 rytvela scrambled peptide Scrambled control peptide for rytvela
August
PP-350 PDHPS1 YAP signaling pathway inhibitor
AM-340 KLA peptide Proapoptotic mitochondrial membrane disruptor
RT-030 FGF7p FGF7 mimetic
July
TP-030 TIP TRPV1 inhibitor
PI-290 Multi-Leu peptide PACE4 inhibitor
PP-340 Tat-D3S2 DIRAS3 – beclin1 interaction inhibitor
June
PP-330 RS17 CD47 – SIRPα signalling inhibitor
KS-210 MOTS-c AMPK activator
PP-320 VGN50 Blocks MYC activation
May
PI-270 Compstatin C3 convertase inhibitor
PP-310 Rb4 Induces expression of HMGB1 and calreticulin
PI-280 Q14 USP30 inhibitor
April
CK-030 EPI-X4 Endogenous CXCR4 antagonist
HD-010 SAP15 HDAC5 inhibitor
PP-300 NP-12 PD-1/PD-L1 interaction blocker
March
PP-290 KP1 Disrupts TGF-β/TβR2 interaction
CY-030 rytvela IL-1 receptor allosteric antagonist
OR-030 SHBG141–161 GPRC6A agonist
PP-280 TPP-1 Blocks PD-1/PD-L1 interaction
February
IG-050 Synstatin Syndecan-1 mediated integrin activation inhibitor
NR-180 S9pep SOX9 mimetic
PP-270 TAT-ANK Dll4-Notch1 inhibitor
January
CH-010 Chemerin-9 Chemokine-like receptor 1 (CMKLR1) agonist
PP-260 Tat-NTS peptide Blocks the interaction of ANXA1 with importin β
AS-010 NT1–20 Blocks ASIC1a binding to RIPK1
2021
December
TP-020 SOR-C13 TRPV6 antagonist
AM-330 AMPR-22 Antimicrobial peptide derived from Romo1
FZ-010 Fz7-21 Selective FZD7 antagonist
CY-020 S7 Interleukin-6 inhibitor
November
PR-100 P4pal10 PAR4 antagonist
TP-010 tatM2NX Cell permeable TRPM2 antagonist
CK-020 HBP08 CXCL12/HMGB1 heterocomplex inhibitor
EP-020 SFKEELDKYFKNHTSP Epitope from the S2 protein of SARS-CoV-2
FP-030 Atto647N-LPETGG Sortase reagent
October
FP-040 Atto550-LPETGG Sortase reagent
PP-250 A11 ANXA1–EphA2 interaction blocker
AV-010 F9170 Inactivates HIV-1 virions
PP-240 NFAT Inhibitor Calcineurin-NFAT interaction inhibitor
September
PP-230 Tat-CIRP MD2 – CIRP interaction blocker
CR-020 CRF (human, rat) Endogenous CRF receptor agonist
SP-050 Rad17 derived peptide ATR kinase substrate
OX-050 Orexin A (human, rat, mouse) OX1 and OX2 receptor agonist
OR-020 VPM-p15 GPR64 (ADGRG2) agonist
CY-010 S1H Human growth hormone receptor antagonist
PP-220 F1 Blocks the association of IKKbeta and NEMO
August
PP-210 p28 Binds to p53 and inhibits cop1 binding
GL-040 GIP_HUMAN[22–51] Endogenous proatherosclerotic peptide hormone
AM-320 IDR 1002 Innate defence regulator peptide
PP-200 Tat-beclin 1 Autophagy inducing peptide
AM-310 Pexiganan Broad spectrum antibacterial agent
July
PP-170 Caveolin-1 scaffolding domain peptide The binding domain of caveolin-1
PP-120 (D)-PPA 1 PD-1/PD-L1 interaction inhibitor
PP-040 Tat-βsyn-degron α-Synuclein knockdown peptide
PP-110 Foxy 5 Wnt5a mimetic peptide
PP-030 KSL 128114 Binds the PDZ1 domain of syntenin
June
AM-300 SAAP 148 Antimicrobial peptide derived from LL-37
AM-290 Pap12-6 Antibacterial derived from the N-terminus of papiliocin
AM-280 BING Antimicrobial peptide from Japanese medaka fish
