chromatec成立于1999年，是一家致力于提供不同的凝血诊断领域人类和重组蛋白的生物技术公司。此外，chromatec还在蛋白质组学领域提供不同的服务。chromatec的产品普遍被全球范围内的大学、生物技术公司、制药公司和研究机构所使用，并通过了DIN EN ISO 9001:2015认证。

主要生产线

（1）人血小板因子4（Platelet Factor 4 human）

血小板因子4（PF4；也称为CXCL4）在巨核细胞和血小板中合成。血小板因子 4是一种由70个氨基酸组成的蛋白质，由活化血小板的α颗粒释放。它的主要生理作用似乎是中和血管内皮表面的分子，从而抑制局部抗凝血酶III活性并促进凝血。作为中性粒细胞和成纤维细胞的强化学引诱剂，PF4可能在炎症和伤口修复中发挥作用。Oncostatin-A是CXC趋化素家族的成员。人PF4用于证明诱导的血小板减少症。此外，它还用作肿瘤治疗期间血管生成的抑制剂。

chromatec提供重组人血小板因子4、亲和素标记的人血小板因子4、人血小板因子4重组变体、以及抗人血小板因子4抗体系列产品。

（2）颗粒溶素（Granuylsin）

颗粒溶素（GNLY）是细胞毒颗粒蛋白，与穿孔素和颗粒酶共同定位于人的细胞毒T淋巴细胞（CTL）和自然杀伤细胞（NK）溶细胞颗粒中，也释放至健康人和患者外周血中。GNLY是机体抵抗多种病原微生物和杀灭肿瘤细胞的重要物质。

（3）血小板膜糖蛋白II b / III a（glycoprotein II b / III a）

chromatec提供分离自人血小板的血小板膜糖蛋白II b / III a。

使用chromatec的产品发表的部分文献：

1. Bertini S, Fareed J, Madaschi L, et al. Characterization of PF4-Heparin Complexes by Photon Correlation Spectroscopy and Zeta Potential. Clin Appl Thromb Hemost. 2017; doi: 10.1177/1076029616685430

http://journals.sagepub.com/doi/abs/10.1177/1076029616685430?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

2. Nguyen T-H, Greinacher A, Delcea M. Quantitative description of thermodynamic and kinetic properties of the platelet factor 4/heparin bonds. Nanoscale. 2015; 7:10130-10139

http://pubs.rsc.org/en/Content/ArticleLanding/2015/NR/C5NR02132D#!divAbstract

3. Arman M, Krauel K, Tilley DO, et al. Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4. Blood. 2014;123(20):3166–74.

http://www.bloodjournal。。ｏｒｇ/content/123/20/3166.long?sso-checked=true

4. Block S, Greinacher A, Helm CA, et al. Characterization of bonds formed between platelet factor 4 and negatively charged drugs using single molecule force spectroscopy. Soft matter. 2014;10(16):2775–84.

http://pubs.rsc.org/en/Content/ArticleLanding/2014/SM/c3sm52609g#!divAbstract

5. Schulze A, Jensch I, Krauel K, et al. New insights in heparin-induced thrombocytopenia by the use of fluid-phase assays to detect specifically platelet factor 4/heparin complex antibodies and antibody-secreting cells. Thrombosis research. 2014;134(1):174–81.

http://www.sciencedirect。。ｃｏｍ/science/article/pii/S004938481400228X

6. Kreimann M, Brandt S, Krauel K, et al. Binding of anti-platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4. Blood. 2014;124(15):2442–9.

http://www.bloodjournal。。ｏｒｇ/content/124/15/2442.long

7. Jaax ME, Krauel K, Marschall T, et al. Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4. Blood. 2013;122(2):272–81.

http://www.bloodjournal。。ｏｒｇ/content/122/2/272.long

8. Krauel K, Hackbarth C, Fürll B, et al. Heparin-induced thrombocytopenia: in vitro studies on the interaction of dabigatran, rivaroxaban, and low-sulfated heparin, with platelet factor 4 and anti-PF4/heparin antibodies. Blood. 2012;119(5):1248–55.

http://www.bloodjournal。。ｏｒｇ/content/119/5/1248.long

9. Krauel K, Weber C, Brandt S, et al. Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopes. Blood. 2012;120(16):3345–52.

http://www.bloodjournal。。ｏｒｇ/content/120/16/3345.long?sso-checked=true

10. Kolde H-J, Dostatni R, Mauracher S. Rapid and simple IgG specific test for the exclusion of heparin induced thrombocytopenia (HIT). Clinical Chemistry and Laboratory Medicine. 2011;49(12):2065–8.

http://www.degruyter。。ｃｏｍ/view/j/cclm.2011.49.issue-12/cclm.2011.693/cclm.2011.693.xml;jsessionid=51EFD1CF9C16145F6D60E19B3BE38680

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