标签归档：glp

BioPorto ABS 033-10B-005 说明书

发表于由

上海金畔专业代理并分销BioPorto糖尿病、肥胖症等代谢疾病相关的单克隆抗体。蛋白质/多肽类激素通常是产生于特定刺激后分泌到循环系统中的激素原，一旦分泌，大多数的肽激素在血液循环自由存在。在穿越血液循环的同时，在靶细胞表面遇到受体，并与特定的内分泌细胞上的细胞表面受体结合。内分泌细胞合成，储存和分泌蛋白质/多肽激素，并再次激活各种信号转导系统，内分泌的紊乱会引起多种代谢疾病。

糖尿病相关

胰高血糖素样肽-1(GLP-1) 存在多种剪切体，包括GLP-1 Extended form、GLP-1 Active form及GLP-1 Metabolite等。BioPorto专业提供针对各种形式GLP-1的单克隆抗体，用于GLP-1糖尿病治疗的研究及检测，为早期研发阶段、临床阶段I和/或在zui终治疗产品的生产和质量控制过程提供可靠依据。

图1 不同形式的GLP-1 (Glucagon-likepeptide1)示意图

提供胰高血糖素样肽-2(GLP-2)、胰多肽(PP)、Exendin-4、胰高血糖素（Glucagon）等糖尿病研究相关单克隆抗体：

货号

产品名称

规格

宿主

应用

ABS 033-04-02

Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)

200µl

Mouse

ELISA, IHC

ABS 033-04-1

Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)

1ml

Mouse

ELISA, IHC

ABS 033-10-02

Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)

200µl

Mouse

ELISA, WB

ABS 033-10-1

Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)

1ml

Mouse

ELISA, WB

ABS 033-10B-005

Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)

50µl

Mouse

ELISA

ABS 044-49-02

Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)

200µl

Mouse

ELISA, WB

ABS 044-49-1

Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)

1ml

Mouse

ELISA, WB

ABS 044-53-02

Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)

200µl

Mouse

ELISA, WB

ABS 044-53-1

Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)

1ml

Mouse

ELISA, WB

ABS 046-03-02

Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific)

200µl

Mouse

ELISA, WB

ABS 046-03-1

Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific)

1ml

Mouse

ELISA, WB

ABS 046-03B-005

Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific)

50µl

Mouse

ELISA

HYB 011-05-02

Glucagon-like peptide-1 (GLP-1(1-36)amide, N-terminal-extension specific)

200µl

Mouse

ELISA, WB

HYB 011-05-1

Glucagon-like peptide-1 (GLP-1(1-36)amide, N-terminal-extension specific)

1ml

Mouse

ELISA, WB

HYB 147-06-02

Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific)

200µl

Mouse

ELISA, IHC

HYB 147-06-1

Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific)

1ml

Mouse

ELISA, IHC

HYB 147-06B-005

Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific)

50µl

Mouse

ELISA

HYB 147-08-02

Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

200µl

Mouse

ELISA, WB

HYB 147-08-1

Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

1ml

Mouse

ELISA, WB

HYB 147-08B-005

Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

50µl

Mouse

ELISA

HYB 147-12-02

Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

200µl

Mouse

ELISA, WB, IHC

HYB 147-12-1

Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

1ml

Mouse

ELISA, WB, IHC

HYB 147-12B-005

Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

50µl

Mouse

ELISA

HYB 147-13-02

Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

200µl

Mouse

ELISA, WB

HYB 147-13-1

Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)

1ml

Mouse

ELISA, WB

HYB 006-02-02

Glucagon-like peptide-2 (human, GLP-2)

200µl

Mouse

ELISA

HYB 006-02-1

Glucagon-like peptide-2 (human, GLP-2)

1ml

Mouse

ELISA

ABS 030-06-02

Pancreatic Polypeptide (human, PP)

200µl

Mouse

ELISA, WB

ABS 030-06-1

Pancreatic Polypeptide (human, PP)

1ml

Mouse

ELISA, WB

HYB 347-06-02

Pancreatic PolyPeptide (PP)

200µL

Mouse

ELISA

HYB 347-06-1

Pancreatic PolyPeptide (PP)

1ml

Mouse

ELISA

ABS 012-20-02

Exendin-4

200µl

Mouse

ELISA

ABS 012-20-1

Exendin-4

1ml

Mouse

ELISA

ABS 012-24-02

Exendin-4

200µl

Mouse

ELISA

ABS 012-24-1

Exendin-4

1ml

Mouse

ELISA

ABS 012-35-02

Exendin-4

200µl

Mouse

ELISA

ABS 012-35-1

Exendin-4

1ml

Mouse

ELISA

ABS 012-35B-005

Exendin-4

50µl

Mouse

ELISA

ABS 058-08-02

Glucagon (human, pig, rat)

200µl

Mouse

ELISA

ABS 058-08-1

Glucagon (human, pig, rat)

1ml

Mouse

ELISA

ABS 058-08B-005

Glucagon (human, pig, rat)

50µl

Mouse

ELISA

ABS 061-09-02

Glucagon (human, pig, rat)

200µl

Mouse

ELISA

ABS 061-09-1

Glucagon (human, pig, rat)

1ml

Mouse

ELISA

 

Anti-GLP-1(7-37) and GLP-1(7-36)amide (N-terminal specific)

CAT.NO. ABS 033-10B

DELIVERY: 1-5 DAYS

 

Cat. No.

ABS 033-10B

Product name

Anti-GLP-1(7-37) and GLP-1(7-36)amide (N-terminal specific)

Description

Mouse monoclonal antibody, biotinylated

Specificity

ABS 033-10 binds the free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide and shows <0.2% cross-reactivity with GLP-1(9-36)amide, glucagon and human GIP. Cross-reacts 0.25% with GLP-1(1-37), approximay 6% with human GLP-2 and approximay 50% with exendin-4. ABS 033-10 cross-reacts with Liraglutide.聽

Immunogen

Synthetic GLP-1(7-17)聽

Application

ELISA

Species reactivity (positive)

Human

Species reactivity (negative)

Not determined

Subclass

IgG2a/k

Gene ID

2641

Clone number

10

Epitope

Free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide.

Content

50 碌L, 1 mg/mL +/- 15%. See Certificate of Analysis for details.

Purification

Biotinylated

Form

Liquid

Solvent

0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15 mM sodium azide

Storage

4-8ºC without exposure to light. No precautions necessary during handling.

Target

Glucagon-like peptide 1(7-36)amide (GLP-1(7-36)amide) is the principal active form of GLP-1, the other being GLP-1(7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.

 

我们公司zui大优势是强大的采购，

1：基本什么都能进口，血清，抗体，耗材，还有部分限制进口的，

2：货品全，现经营过700多个品牌，基本所有生物试剂耗材都可以进口，特别是冷偏的产品那就更有优势，

3：提供加急服务，一般1-2周到货，超过时限加急费全免

4：价格公道，绝大部分价格有优势，当然不能保证100%产品都是,因为意味着没有服务.

5：良好的信誉，大部分客户我们提供货到付款服务，客户包括清华，北大 交大 复旦，中山等100多所大学，ROCHE，阿斯利康，国药 ，fisher等500多家公司

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xenometrix2022年产品目录

发表于由

Xenometrix 于 1995 年 6 月在瑞士 Allschwil 成立。从那时起，专门从事细胞生物学、生物化学、免疫学领域的科学家加入了公司。已经建立了全球分销商网络以及 GLP 和非 GLP 条件下的服务分析网络。

我们的愿景是为 Ames 测试、内分泌干扰物测定、皮肤吸收测试或细胞毒性测试系统等生物测定提供质量和服务。Xenometrix 产品用于分子药理学、药物发现的早期阶段、化学品筛选、农用化学品、杀生物剂、化妆品、食品以及用于测试环境水、土壤、空气或污水。

xenometrix C01-512-S1-P

Ames MPF Penta 1 – 1 Sample Ames Test Kit

货号：C01-512-S1-P

单位
5 x 48 个测量点：5 个菌株（TA98、TA100、TA1535、TA1537、大肠杆菌 uvrA/E.coli pkM101）中的 1 个样品，如果在 3 次重复、6 次稀释、+/- 1254 Aroclor 诱导的 S9、阴性和阳性对照。不包括在试剂盒中：S9 辅因子溶液、微孔板
描述

用于 Ames 测试的即用型入门套件，包括半固体 TA98、TA100、TA1535、TA1537、E.coli WP2 uvrA、E.coli WP2 pKM101、Booster、Growth -、Exposure -、Reversion Indicator Media、Positive Controls、Post -来自冻干的Aroclor 1254诱导的大鼠肝脏的线粒体上清液S9。

特征

  • 质量控制试剂：菌株、S9、培养基、阳性对照 – 无需内部质量控制，无需无菌控制   

  • 提供分析证书

  • 支持数据解释的 Excel 计算表

  • 测试数量对应于 5 x 480 琼脂板。

  • 标准化程序

  • 足够的材料来单独处理应变

  • 在室温下从德国或瑞士的外部存储中运送

  • 与琼脂平板测试的高灵敏度和出色的相关性（参见参考文献）

  • 与琼脂平板测试相比，测试化合物减少 4 倍

  • 减少手动操作时间和同时处理多个重复

  • 可用自动化 – 高吞吐量

  • 大鼠肝脏 S9 消耗量减少 3Rs – 12 倍，牺牲的测试动物显着减少

  • 由于易于比色读数，不易出错

  • 废物 – 显着减少塑料废物，从而减少环境中的污染废物

 

单独提供： S9 辅因子套件（Art.No. PCO-0800）

也提供：

  • C01-512-S2-P Ames MPF Penta 1 与 S9 来自冻干 PB/ß萘黄酮诱导的大鼠肝脏*

  • 使用 Ames MPF 进行 Ames 测试的单个产品，例如 S9、培养基、阳性对照等。

  • D05-210 MicroAmes24，在 24 孔琼脂板上进行小型 Ames 测试

  • K05-210 NanoAmesTM，超小型 Ames 测试，用于测试极少量的“µg”样品量或混合物，正在开发中的试剂盒 

  • 在 GLP 和非 GLP 条件下使用所有技术进行 Ames 测试的服务分析

*请注意，Aroclor 1254 与关于持久性有机污染物的斯德哥尔摩公约相冲突，已被禁用。因此，未来无法保证 Aroclor 1254 诱导的 S9 的可用性。

xenometrix2022年产品目录

 Product Article No.
Ready to use Ames Test Kits
Ames MPF PENTA 1 – 5 Strain Kit – 
10 Sample Kit  –  480 Measuring Points / Strain C10-512
10 Sample Kit with S9  and Positive Controls
Same components as in C10-512, plus positive controls and: 
ŸLyophilized rat liver S9, Aroclor 1254 induced or C10-512-S1-P
ŸLyophilized rat liver S9, Phenobarbital/β-Naphtoflavone induced C10-512-S2-P
1 Sample Starter Kit –  48 Measuring Points / Strain
ŸLyophilized rat liver S9, Aroclor 1254 induced or C01-512-S1-P
ŸLyophilized rat liver S9, Phenobarbital/β-Naphtoflavone induced C01-512-S2-P
Ames MPF PENTA 2 – 5 Strain Kit
10 Sample Kit  –  480 Measuring Points / Strain B10-513 
10 Sample Kit with S9  and Positive Controls
Same components as in C10-512, plus positive controls and: 
ŸLyophilized rat liver S9, Aroclor 1254 induced or B10-513-S1-P
ŸLyophilized rat liver S9, Phenobarbital/β-Naphtoflavone induced B10-513-S2-P
1 Sample Starter Kit –  48 Measuring Points / Strain
ŸLyophilized rat liver S9, Aroclor 1254 induced or B01-513-S1-P
ŸLyophilized rat liver S9, Phenobarbital/β-Naphtoflavone induced B01-513-S2-P
Ames II – 2 Strain Kit
10 Sample Kit  –  480 Measuring Points / Strain E10-213
10 Sample Kit  with S9 and Positive Controls
Same components as in E10-213 plus positive controls and:
ŸLyophilized rat liver S9, Aroclor 1254 induced E10-213-S1-P
ŸLyophilized rat liver S9, Phenobarbital/β-Naphtoflavone induced E10-213-S2-P
Ames MPF 98/100
10 Sample Kit  –  480 Measuring Points / Strain A10-210
10 Sample Kit with S9 and Positive Controls
Same components as in A10-210, plus positive controls and:
ŸLyophilized rat liver S9, Aroclor 1254 induced or A10-210-S1-P
ŸLyophilized rat liver S9, Phenobarbital/β-Naphtoflavone induced A10-210-S2-P
1 Sample Starter Kit –  48 Measuring Points / Strain
ŸLyophilized rat liver S9, Aroclor 1254 induced or A01-210-S1-P
ŸLyophilized rat liver S9, Phenobarbital/β-Naphtoflavone induced A01-210-S2-P
Ames MPF 98/100 Aqua
5 Sample Basic Kit without S9, positive controls – 240 Measuring Pts. J05-210
5 Sample Kit –  240 Measuring Points / Strain
Same components as in J05-210, plus positive controls and:
ŸLyophilized rat liver S9, Aroclor 1254 induced or J05-210-S1-P
ŸLyophilized rat liver S9, Phenobarbital/β-Naphtoflavone induced J05-210-S2-P
MicroAmes24 98/100 – 24 Well Agar Plate Test
5 Sample Basic Kit without S9, Positive Controls – 600 Measuring Pts. D05-210
To complete your kit with positive controls and S9, please add
1 ml Phenobarbital/β-Naphtoflavone induced lyophilized rat liver S9 or PRS-PB01
2 ml Phenobarbital/β-Naphtoflavone induced lyophilized rat liver S9 PRS-PB02
2-Nitrofluorene, 2-NF, 20 µg PPC-NF00
2-Aminoanthracene, 2-AA, 100 µg         PPC-AA01
4-Nitroquinoline-N-oxide, 4-NQO, 50 µg   PPC-NQ02
S9 Cofactor Solution Kit  PCO-0800
NanoAmes 98/100 – 25 Well Agar Plate Test
5 Sample Basic Kit without S9, Positive Controls  K05-210
To complete your kit with positive controls and S9, please add
1 ml Phenobarbital/β-Naphtoflavone induced lyophilized rat liver S9 or PRS-PB01
2 ml Phenobarbital/β-Naphtoflavone induced lyophilized rat liver S9 PRS-PB02
2-Nitrofluorene, 2-NF, 20 µg PPC-NF00
2-Aminoanthracene, 2-AA, 100 µg         PPC-AA01
4-Nitroquinoline-N-oxide, 4-NQO, 50 µg   PPC-NQ02
S9 Cofactor Solution Kit  PCO-0800
Ames Media, Strains, Rat Liver S9, Positive Controls
Ames MPF Media
Ames  MPF / Ames II –  Ready to use Media
Ames MPF / Ames II Growth Medium, 50 ml PMM-GM00
Ames MPF / Ames II Salmonella Exposure Medium, 50 ml PMM-EM02
Ames MPF / Ames II Salmonella Reversion Indicator Medium, 550 ml PMM-IM10
Ames  MPF E.coli  –  Ready to use Media
Ames MPF/Ames II Growth Medium, 50 ml PMM-GM00
Ames MPF E.coli Exposure Medium, 50 ml PME-EM22
Ames MPF E.coli Reversion Indicator Medium, 550 ml PME-IM31
Ames  MPF 10x Exposure Media –  Ready to use Media
Solution A – 25 ml / Solution B – 0.7 ml PMM-EM03
Bacterial Strains
Ames – Semisolid S. typhimurium Strains 
50 µl   TA98          PSS-0110
50 µl   TA100       PSS-0111
50 µl   TA1535       PSS-0112
50 µl   TA1537     PSS-0113
50 µl   TA97a    PSS-0114
Shipping: room temperature (cool packs)  / Storage: -70oC
Ames – Liquid S. typhimurium Strains 
50 µl   TA98         PLI-0110
50 µl   TAMix        PLI-0114
Shipping: dry ice / Storage: -70oC
Ames – Semisolid E.coli Strains
50 µl   E.coli WP2 uvrA     PSS-0115
50 µl   E.coli WP2 [pKM101]   PSS-0116
50 µl   E.coli WP2 UvrA[pKM101]   PSS-0119
Shipping: room temperature (cool packs)  / Storage: -70oC
Ampicillin
120 µl  Ampicillin PAM-0002
Rat liver S9 , Co-factor Solutions
1 ml Aroclor 1254 induced lyophilized rat liver S9  PRS-AC01
2 ml Aroclor 1254 induced lyophilized rat liver S9  PRS-AC02
0.4 ml Phenobarbital/β-Naphtoflavone induced lyoph. rat liver S9 PRS-PB00
1 ml Phenobarbital/β-Naphtoflavone induced lyoph. rat liver S9 PRS-PB01
2 ml Phenobarbital/β-Naphtoflavone induced lyoph. rat liver S9 PRS-PB02
S9-100/1537 Booster Solution PRS-BB01
S9 Cofactor Kit for Ames MPF, Ames II
At least 20 Assays, S9-Buffer-Salts, S9-G-6-P, S9-NADP PCO-0800
Positive Controls for Ames MPF, Ames II
2-Nitrofluorene, 2-NF, 20 µg PPC-NF00
2-Aminoanthracene, 2-AA, 100 µg         PPC-AA01
4-Nitroquinoline-N-oxide, 4-NQO, 50 µg   PPC-NQ02
N4-Aminocytidine, N4-ACT, 2.5 mg   PPC-AC02
9-Aminoacridine, 9-AAC, 1000 µg PPC-AR05
2-Aminofluorene, 2AF, 10 mg  PPC-AF10
Plastic Ware
Plastic Ware  –  Large Packages
Sterile 96-well plate, 160 plates  PPW-8100
Sterile 24-well plates, 126 plates  PPW-0725
Sterile 25 Well Square Plates, 4 Plates PPW-
Sterile 384-well plates,  50 plates PPW-0924
Test Kit UmuC Easy CS
6 Sample Kit  –  192 Measuring Points G06-118-P
2 vials TA1535psK1002
2 vials ampicillin
Positive controls
Media and Reagents
To complete your kit with lyophilized rat liver S9 please add:
1 ml Phenobarbital/β-Naphtoflavone induced lyophilized rat liver S9 PRS-PB01
Micronucleus Assay Kit with FISH Probes
Rapid Micronucleus MoA
20 Slides / Kit  M020
100 Slides / Kit  M100
Test Kits for Endocrine Disruptor Chemicals 
XenoScreen YES / YAS
5 -10 Sample Kit, controls LoD, LoQ – 348 Measuring Points N05-233-Y
Analysis of 5 compounds, agonistic and antagonistic activities,
or 10 compounds for agonistic activity only, duplicates,  
7 concentrations, calibration curves, negative and positive controls
without Yeast Saccharomyces cerevisiae hER and  hAR – to complete
your kit with yeast Saccharomyces cerevisiae hER and yeast Saccharomyces cerevisiae hAR, please add
XenoScreen YES Strain, 1 vial N05-230-E
XenoScreen YAS Strain, 1 vial N05-230-A
XenoScreen XL YES / YAS
4 – 8 Sample Kit, controls LoD, LoQ,- 348 Measuring Points N04-233-Y
Analysis of 4 compounds, agonistic and antagonistic activities,
or 8 compounds for agonistic activity only, duplicates,  
7 concentrations, calibration curves, negative and positive controls
without Yeast Saccharomyces cerevisiae hER and  hAR – to complete
your kit with yeast Saccharomyces cerevisiae hER and yeast Saccharomyces cerevisiae hAR, please add
XenoScreen YES Strain, 1 vial N05-230-E
XenoScreen YAS Strain, 1 vial N05-230-A
XenoScreen XL YES (YES agonist assay only)
4 or 32 Sample Kit, controls LoD, LoQ – 96 Measuring Points N32-233-Y
Analysis of 4 compounds, agonistic activities only, duplicates,
7 concentrations, calibration curves or 32 samples at 1 concentration  
negative and positive controls
without Yeast Saccharomyces cerevisiae hER – to complete 
your kit with yeast Saccharomyces cerevisiae hER, please add
XenoScreen YES Strain, 1 vial N05-230-E
XenoScreen XL YAS (YAS agonist assay only)
4 or 32 Sample Kit + controls LoD, LoQ – 96 Measuring Points N32-234-Y
Analysis of 4 compounds, agonistic activities only, duplicates,
7 concentrations, calibration curves or 32 samples at 1 concentration  
negative and positive controls
without Yeast Saccharomyces cerevisiae hAR – to complete 
your kit with yeast Saccharomyces cerevisiae hAR, please add
XenoScreen YAS Strain, 1 vial N05-230-A
XenoScreen YES / YAS Accessories
XenoScreen YES Strain, 1 vial N05-230-E
XenoScreen YAS Strain, 1 vial N05-230-A
XenoScreen XL YES / YAS Culture Maintenance Set N05-PMY-7
For passages / c*tion of the yeast cells
Cytotoxicity Assays
XTT Tetrazolium hydroxide
1200 tests  KXT 96.1200