SCHIRCKS 16.411 说明书

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Product No. 16.411

Synonym: Amethopterin, N-methylamino}benzoyl}-L-glutamic acid

Abbreviation used: MTX


Yellow to orange brown crystalline powder




Methotrexate is an antimetabolite. It is an inhibitor of dihydrofolate reductase. MTX acts by


altering the body's use of folic acid (a vitamin), which is needed for cell growth. It is


suspected that this interference with folic acid is an important reason for methotrexate's


benefit in rheumatoid arthritis.





MTX is practically insoluble in water. It is sparingly soluble in 0.01 M NaOH pH 10.0,


(0.25 g/100 g 0.01 M NaOH (22°C)). Ultrasonication may be used to improve dissolution.

HPLC Conditions



Waters Spherisorb S5-ODS1






10 mM Na2HPO4 pH 6.0 / Methanol (19:1)


flow rate


1 ml/min







254 nm







1 mg/ml 0.01 M NaOH



Purity: HPLC

>98.5%. Related substances are N-methylfolic acid, 4-aminofolic acid, 2,4-diami0-


methylpteroic acid and 10-methylpteroic acid.




Methotrexate powder is stable at room temperature for at least 3 months. It is hygroscopic.


A 1 mM solution of MTX in 0.01 M NaOH is very stable. HPLC analysis of the 1 mM solution


after 7 days at room temperature showed no degradation.


Keep the powder dry in amber vials at –20°C or colder. Methotrexate can be transported


without the use of dry ice.





MTX was first developed to treat certain types of cancer. It is routinely used at high doses


as a cancer therapy and is also used at much lower doses to treat neoplastic diseases,


severe psoriasis, Crohn's disease and adult rheumatoid arthritis. Our product is sold for


laboratory use only.





Highly Toxic. Use Special Handling precautions. Avoid inhalation and skin contact.


Side effects to the use of this drug may include suppression of bone marrow production of


blood cells, hepatitis, and others.





“Taber's Cyclopedic Medical Dictionary”, Copyright © 2001 by F. A. Davis Co., Phil., PA.